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Generic Name: Rabeprazole

Brand Names: Aciphex

Dosage Package: 20 mg, 10 mg

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What is Aciphex?

Aciphex is an antiulcer product of the new generation. It is produced in the form of tablets covered by the enteric coating. These tablets are dissolved in the digestive tract and bind to the receptors of the stomach and intestine that may block a proton pump. The proton pump regulates a concentration of hydrochloric acid in the gastric juice. Blocking its work, an acidity is reduced in the gastro-intestinal tract.

The use of Aciphex helps to reduce a formation of ulcers on the mucous membrane of the gastro-intestinal tract, fasten the treatment of gastric ulcer and other diseases caused by the excessive secretion of hydrochloric acid.

The maximal reduction of pH in the stomach is recorded in 2-4 hours after the use of the first dose. The action of Aciphex is reversible, and the work of the proton pump is restored in a week after the end of the therapy.

Who should take Aciphex?

Aciphex is prescribed patients with the increased acidity of the gastric acid, and also during the following diseases:

  • Ulcer disease of the stomach and duodenum in the acute stage
  • Gastroesophageal reflux disease
  • Zollinger-Ellison syndrome

Aciphex may be used in the treatment of the gastric ulcer caused by Helicobacter pylori as a part of the antibacterial therapy.

How to take Aciphex?

Aciphex are the pills which are dissolved in the stomach after the peroral use. You should take the pills every day, at the same time. It is better to take Aciphex in the morning, 20 minutes before breakfast. Do not chew or break the pill. Take it with a glass of water.

A standard therapeutic dose of Aciphex is 20 mg per day. It is prescribed during any forms of the hypersecretion of the gastric acid and relevant diseases.

A course of the administration may vary:

  • The treatment takes 1,5 months to treat acute state of the gastric and duodenum ulcer
  • Refluxe esophagitis takes 1-2 months
  • Gastric ulcer caused by Helicobacter pylori takes 7-10 days

What are side effects?

The side effects of Aciphex are moderate. The symptoms often appear within the first week of the treatment, during the maximal adaptation of the body to the drug action.

A patient may have the following side effects within the first week of the use of Aciphex: diarrhea, nausea, vomiting, stomachache, bloating, low appetite, and increase of liver transaminase. These side effects often occur in the gastro-intestinal tract.

Following all recommendations will minimize the intensity of the side effects and avoid a physical or psychological discomfort.

Special recommendations

  • Do not take the Aciphex pills with grape or grapefruit juice. It may reduce the efficiency of the pill and increase a production of the gastric acid
  • Do not consume alcohol, spicy food, fatty or difficult digestible food
  • If a patient has severe liver disorders, consult a doctor before using Aciphex
  • Make sure that the symptoms of the gastric ulcer are not caused by malignant tumors. It a tumor is detected, the treatment is stopped
  • Pregnant women may take Aciphex only after doctor’s permission.


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