Tetracyclines are one of the first antibiotics used to treat bacterial infections. Now, bacteria have a resistance to many tetracyclines but Doxycycline still keeps its medical value and is effectively used in the treatment of the different infections.
Doxycycline is a semisynthetic antibiotic from the group of tetracycline which provides a broad antimicrobial action. This is one of the most effective tetracyclines on the modern pharmaceutical market. A resistance of the pathogenic microflora is hardly developed to Doxycycline, but it may be used only for certain therapeutic indications.
Doxycycline provides a bacteriostatic action to the pathogenic microflora. It inhibits a synthesis of protein inside the cells of the infection originators, and bacteria stop growing.
After the peroral use of Doxycycline, it is completely absorbed from the gastro-intestinal tract and is spread in the tissues and liquids in the body. It is not metabolized in the body and is excreted intactly by kidneys (about 40%) and with stool in 12-20 hours. That is why, patients with kidney dysfunction should be prescribed an individual dose in order to avoid an accumulation of this antibiotic in the body.
Indications for the use
- Sexually Transmitted Infections: syphilis, chlamydia, inguinal granuloma
- Infections of the lower and upper respiratory tract: acute exacerbations of chronic bronchitis, community-acquired pneumonia
- Gynecological and urological infections
- Intestinal infections
- Infections of the skin and soft tissues, including acne
- Wound infections after being bitten by animals.
In what dose is Doxycycline used?
The dosage regimen of Doxycycline is prescribed after considering a medical image of a patient. The pills should be taken on an empty stomach, 1 hour before or in 2 hours after meals.
Adult patients and teenagers with the body weight more than 45 kg are prescribed Doxycycline 100 mg 2 times per day (in the morning and evening) to treat infections of the middle severity. Doxycycline 100 mg is used once per day on the second and next days of the treatment.
To treat urological/gynecological infections and sexually transmitted infection, Doxycycline 100 mg is taken 2-3 times per day within 7-14 days. The treatment lasts for up to 4 weeks if the intense medical effect is absent. The maximal daily dose of Doxycycline is 300 mg.
Using high doses of Doxycycline (more than 600 mg per day) may cause neurotoxic reactions: vomiting, seizures, impaired consciousness due to increased intracranial pressure. A severe allergic reaction is also possible during the overdose.
Patients are prescribed a stomach lavage and drugs for a faster excretion of the antibiotic from the body during the overdose with Doxycycline.
- Doxycycline lowers the efficiency of the bactericidal antibiotics, and therefore the simultaneous use is not recommended
- Ethanol has a negative influence on the pharmacological action of Doxycycline
- The simultaneous use of Doxycycline with Retinol (Vitamin A) enhances the intracranial pressure
- Doxycycline (as other tetracyclines) are contraindicated women during pregnancy and children under 10 years old. It is accumulated in the child’s baby and causes an inhibition of the growth of bones, teeth, and severe liver pathologies
- Do not take Doxycycline during hepatic failure, intolerance of lactose or if you weigh less than 45 kg.