What is Glucophage?
Glucophage is a trading name of the active ingredient Metformin. This ingredient is one of the most popular drugs for the treatment of pancreatic diabetes. The ingredient has been used within 40 years in the medical practice, and it is still leading nowadays.
A peculiarity of the drug is a reduction of the sugar level in the blood without causing hypoglycemia. It does not stimulate secretion of insulin and does not provide a hypoglycemic action in healthy people unlike derived Sulfonylurea. Glucophage does not influence on the secretion of insulin, and therefore it does not normally have side effects and is well tolerated.
The action of Glucophage happens by means of the destruction of the sensitivity of glucose to insulin. A patient should not take insulin additionally because the body will produce enough volume of it to process glucose.
Using Glucophage before meals, its active ingredients reduce the absorption of glucose in the intestine, so that patients may reduce the amount of the consumed sugar, and they successfully cope with the excessive body weight.
Who should take Glucophage?
Glucophage is prescribed patients with pancreatic diabetes type 2 when drug-free methods do not help. The drug is especially effective in fatty people because it helps to gradually reduce the volume of subcutis (in case of following a balanced diet).
How to take Glucophage?
Glucophage is produced in tablets in the dose of 500, 850, and 1000 mg. The drug is used before meals but not more than 3 times per day. It is better to take the medicine before main meals. The use of Glucophage 1-2 times per day will be enough for some patient. In this case, it is necessary to take the tablets in the morning (before breakfast) and in the evening (before supper). The frequency of the drug use and a daily dose depend on the concentration of glucose in the blood.
1000-2000 mg of Glucophage per day are recommended during the average rates of the sugar level in the blood (8-8,5 mmol/L).
The treatment of pancreatic diabetes does not take 1-2 weeks, and therefore the drug is usually used in a regular basis, or within 6 months with some interval. The experienced patients already know when they have to increase the dose, or reduce the dose of Glucophage in order to control the glucose level in the blood.
What are side effects?
Most side effects related to the use of Glucophage occur in the gastro-intestinal tract. These are metallic taste in the mouth, low appetite, diarrhea, and bloating. These side effects do not bother during a long-term treatment, but many patients complain of different negative symptoms at the beginning of the treatment.
There is information that a long-term use of Glucophage in high doses may reduce the level of testosterone in men, the level of thyrotrophic hormone, or it may affect the absorption of some vitamin from the B group.
- Glucophage may be used with other hypoglycemic products including Sulfonylurea drugs. But a dose of both medicines should be reduced
- It is important to regulate the kidney functions during the treatment
- If lactacidemia developed, the use of Metformin should be immediately stopped
- If you are going to have a complex surgery, or you have had burnings/traumas, you probably should stop the use of Glucophage. Consult a physician.