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Generic Name: Procyclidine

Brand Names: Kemadrin

Dosage Package: 5 mg

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What is Kemadrin?

Kemadrin is a medical product which is used for the symptomatic treatment of Parkinson’s disease. It has a low toxicity and effectively helps to reduce tremor and muscle stiffness.

The mechanism of the action of Kemadrin consists in blocking of muscarinic receptors. As a result of blocking these receptors, an agitation of the central nervous system is reduced. In fact, the drug takes part in complex biochemical and physiological processes in the body, as a result of which the work of the nervous system is improved.

Who should take Kemadrin?

Kemadrin is prescribed patients with Parkinson’s disease for the symptomatic control of tremor of extremities and head.

The drug may be also used by people with medical extrapyramidal disorders in order to control the symptoms of this disease.

How to take Kemadrin?

If you have never used Kemadrin, the treatment should be started from the minimal daily dose of 2,5 mg 2-3 times per day. The pills are used after meals, with a glass of water. A therapeutic effect develops within a week. It gradually grows, and therefore you will better control tremor in 10-14 days than at the beginning of the treatment.

If severe side effects do not appear within 2 weeks, the daily dose may be increased. A dose should be increased step by step, by 2,5 mg per day but not more than once in 3 days. The maximal daily dose of Kemadrin is 15 mg (a pill of 5 mg 3 times per day).

Senior patients are not recommended to take more than 10 mg per day.

If the increase of the dose causes side effects, it is necessary to reduce a dose for a short period.

The treatment is continued till the use of Kemadrin effectively copes with tremor and other symptoms of Parkinson’s disease. If you noticed that the use of 15 mg per day does not give enough effect, the treatment is stopped. Perhaps, it is necessary to change a medicine.

What are side effects?

All blockers of muscarinic receptors have side effects that appear in every patient differently. The side effects are usually manifested within the first 2 weeks, and then they are reduced. But if you are going to take Kemadrin, you should be ready for some symptoms: dry mouth, constipations, urine retention, disorder of the tactile sense, dizziness, and sleepiness.

Old people experience side effects more often, and therefore they should take a lower dose. Moreover, they may have confusion and hallucinations.

Special recommendations

  • Do not take more than 15 mg of Kemadrin per day because the exceeding of the maximal dose may cause serious side effects in the central nervous system
  • Patients with closed-angle or open-angle glaucoma are contraindicated to take this medicine
  • If you have any ophthalmologic diseases, consult a doctor before using Kemadrin
  • Patients with diseases of the cardiovascular system and chronic diseases of the abdominal cavity organs should take Kemadrin with high caution.


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