A cause of epilepsy may be traumatic brain injury, oxygen deficiency of the brain and even infectious diseases. Fortunately, epilepsy may be cured regardless of the causes. One of the most effective medicines for the epilepsy treatment is Neurontin.
Neurontin is a cyclic pharmacological analogue of gamma-aminobutyric acid and is approved by FDA to treat epilepsy. It contains an active ingredient Gabapentin.
The mechanism of the pharmacological action of Neurontin differs from most drugs used for the treatment of epilepsy (barbiturates, benzodiazepines, inhibitors of GABA-transaminase and others).
Neurontin affects certain channels of neurons in the central nervous system and stabilizes its action. Using Neurontin happens an improvement of the blood circulation in the brain tissues, reduces the agitation of neurons and convulsive activity.
The work of the central nervous system is stabilized during the recovery of the natural metabolic processes in the brain and the frequency of the epileptic attacks is reduced.
Indications for the use
- Treatment of partial epilepsy in children aged 3-12 years
- Treatment of partial seizures in adults and teenagers over 12 years
- Treatment of neuropathic pain in patients older than 18 years.
In what dose is Neurontin used?
To treat partial attacks of epilepsy in children at the age of 3 to 12 years old, it is recommended to take a pill of Neurontin 200-400 mg per day. Children with the body weight more than 25 kg should take a pill of Neurontin 300-600 mg per day.
Adults and teenagers over 12 years old are prescribed 600-900 mg of Neurontin per day depending on the frequency of the epilepsy attacks.
Adults with severe form of epilepsy may enhance the daily dose up to 3600 mg of Neurontin per day. A decision about changing the dose should be made by a physician on the basis of the medical image of a patient and efficiency of Neurontin in certain medical case.
Neurontin capsules are indicated for the peroral use. They can be used before or after meals, with a full glass of water.
Patients with neuropathic pain are prescribed Neurontin 900 mg three times per day (a pill of Neurontin 300 mg in the morning, in the afternoon and in the evening).
The following side effects appear during the overdose with Neurontin: dizziness, double vision, impaired speech, drowsiness, lethargy and mild diarrhea. The side effects completely pass during the in-time symptomatic therapy.
- Antacids reduce the bioavailability of Gabapentin by 20%, and therefore the interval between the use of these products should be at least 2 hours
- The interaction of Neurontin with other anti-epileptic products is not detected. However, there is a risk of the mutual increase of the pharmacological action, and therefore it is necessary to control a patient state by adjusting the dose
- Anti-epileptic drugs including Neurontin may enhance a risk of the suicidal thoughts or behavior. Therefore patients taking these drugs should be carefully controlled to detect the appearance or worsening of the depression
- The frequency of the muscle spasms may be increased during the use of Neurontin
- Neurontin is not prescribed children under 3 years old and patients with intolerance of lactase.