Opioid analgesics have many side effects but they are required in the treatment of severe pain. Oxycontin is one of the strongest narcotic analgesics of the new generation which is effective during painful syndrome of any severity.
Oxycontin is a semisynthetic opioid analgesic which is used for the treatment of the painful syndrome of the higher severity. It contains an active ingredient Oxycodone which is synthesized of opium poppy.
Oxycontin has been developed to replace morphine and codeine which often cause a narcotic addiction. The pharmacological safety of Oxycontin is higher than in morphine but a lot depends on the correct dose. Even a slight overdose may form an addiction and a patient may develop a resistance to the action of Oxycodone.
The mechanism of the action of Oxycontin is the same as in all opioid analgesics. It stimulates opioid receptors which lower the sensitivity of the nervous endings to pain. Using the drugs enhances the painful threshold regardless of the cause and severity of pain.
Oxycontin is an analgesic of the short period. A one-time therapeutic dose effectively reduces pain for 6 hours, and then it is necessary to take the drug again. A pin-relieving action begins quickly – within 15 minutes after the peroral use. The maximal therapeutic effect is felt in 30-45 minutes.
Indications for the use
- Relief of acute pain during trauma, surgery, metastases in cancer patients
- Prevention of pain during the postoperative period
In what dose is Oxycontin used?
To reduce pain, patients are recommended to take Oxycontin 5-10 mg every 6 hours. If pain is not increased in 6 hours, another dose may be skipped. The more seldom the pills are used, the stronger pain-relieving effect will be and less side effect will appear.
If a pain-relieving effect is weak during the use of Oxycontin 10 mg, the one-time dose should not be increased. The pain-relieving effect may be increased with the help of NSAIDs, acetaminophen, and muscle relaxants depending on the cause of pain.
The maximal daily dose of Oxycontin is 40 mg.
In case of the overdose with Oxycontin, severe side effects appear such asDrowsiness, coma, respiratory arrest, asphyxia, cardiac arrhythmia, vomiting, and allergic reaction. If the first signs of the overdose appear, it is necessary to use antidot, respiratory analeptic agents, have a stomach lavage and go to a doctor.
- The interaction of Oxycontin with other narcotic analgesics and ingredients which provide an inhibiting/stimulating action to the central nervous system enhances a risk of the overdose and a medical interaction
- NSAIDs, acetylsalicylic acid, muscle relaxants increase the action of Oxycontin
- Oxycontin should be used with Naloxone which slightly reduces a toxic action of Oxycodone and lowers a risk of the development of the narcotic addiction
- Oxycontin is contraindicated during severe cardiovascular diseases, acute mental disorders, respiratory distress due to COPD
- To avoid a withdrawal syndrome, the dose of Oxycontin should be gradually decreased before a complete cancellation of the drug.