The pathological processes are started in the human body because of the deficit of the hormones of the adrenal cortex. Synthetic hormones of the adrenal cortex prevent the pathological changes in the body and restore physiological processes. One of the safest synthetic hormones is Prednisone.
Prednisone is a synthetic hormone of the adrenal cortex which is used for the prevention and treatment of many diseases. The drug belongs to glucocorticosteroids. In liver, Prednisone is metabolized into prednisolone and begins its pharmacological action.
Taking Prednisone may restore physiological processes, broken metabolism, regulate balance of water and mineral salts, and neutralize severe inflammatory and allergic processes.
Prednisone provides an anti-inflammatory, anti-allergic, anti-shock and immunodepressive action. It blocks the release of mediators of allergy and inflammation, redistributes fatty tissue and influences on synthesis of protein in the body.
Indications for the use
- Treatment of high severity of allergic diseases (asthma, anaphylactic shock, urticaria)
- Treatment of diseases of the blood and the haematopoietic system
- Treatment and prevention of systemic connective tissue diseases (rheumatoid arthritis, dermatomyositis, periarteritis nodosa)
- Treatment of inflammatory processes in joints
- Treatment and prevention of liver/heart/skin diseases
- Diseases of the adrenal gland and supplementing of adrenal hormones
In what dose is Prednisone used?
Patients are prescribed Prednisone 20-30 mg per day during the intense deficit of adrenal cortex hormones and development of the pathological processes in the body. The daily dose may be taken entirely or divided into 2-3 times, if you have unpleasant symptoms in the gastro-intestinal tract. The maintaining dose of Prednisone is 5-10 mg per day.
Children are prescribed a dose of Prednisone according to the weight: 1-2 mg per 1 kg of the body weight. The daily dose is divided into 4-6 times in order to lower the risk of the side effects. If the daily dose of Prednisone is divided into several times, most part of the dose should be used in the morning, and other doses are taken in the evening.
The overdose with Prednisone is met seldom and only during the use of high doses. The overdose with Prednisone is characterized by the following symptoms: edema, increased blood pressure (hypertensive crisis), euphoria, agitation, epilepsy, nausea, and vomiting.
The overdose symptoms pass during the dose reduction, taking drugs of potassium and magnesium, and as a rule, the use of glucocorticosteroids should not be stopped.
Prednisone influences on the pharmacological action of many drugs because it affects the process of their metabolism.
- Prednisone lowers the efficiency of: antihypertensive, hypoglycemic drugs, insulin, anticoagulants, some anthelmintic drugs
- The risk of the side effects and toxicity is increased during the interaction of Prednisone withandrogenic drugs, NSAIDs, hormonal contraceptives, antipsychotics, tricyclic antidepressants.
- Prednisone is contraindicated during: acute viral infections, osteoporosis, glaucoma, systemic mycosis
- If an infectious process is developed, the dose of the hormonal drug should be lowered during the use of Prednisone
- The use of Prednisone is not prohibited during pregnancy but the treatment is strictly controlled by a physician.