What is Rifampicin?
Rifampicin is an antibacterial product which is used for the treatment of tuberculosis. Activators of tuberculosis are certain microorganisms that may be resistant to common antibiotics. Therefore, the most effective product is Rifampicin in the treatment of this infectious disease.
The mechanism of the action of the antibiotic consists in the destruction of RNA synthesis in the bacterial cell. A bactericidal action quickly destroys a cellular wall of bacteria and causes a complete death of the pathogenic microflora.
A drawback of Rifampicin is a fast development of resistance in bacteria. Therefore, medical courses should be maximally short and the treatment should be controlled by a doctor. If the resistance has been developed to the action of the antibiotic, its application is pointless, and this may have a negative influence on the baseline therapy of tuberculosis.
Who should take Rifampicin?
Rifampicin is often prescribed patients with tuberculosis but the drug has a broad action, and that is why it may be used during other infectious diseases (mainly caused by resistant staphylococci): osteomyelitis, pneumonia, pyelonephritis, leprosy, meningococcal meningitis.
How to take Rifampicin?
The capsules of Rifampicin are taken on an empty stomach, 30 minutes before meals. To treat tuberculosis, the antibiotic is prescribed in the combination with anti-tuberculosis products.
As a combined therapy of tuberculosis, Rifampicin is used in the dose of 450-600 mg per day. Children under 12 years old are prescribed a dose in accordance to the following scheme: 10-20 mg per 1 kg of the body weight per day. A daily dose is used at once and is not divided into parts.
To treat tuberculosis, Rifampicin is used within 2 months; the treatment of tuberculous meningitis takes 7-9 months. Low doses should be used during a long-term treatment in order to maximally keep the therapeutic effect.
To treat infectious diseases caused by susceptible organisms, Rifampicin is usually prescribed as an addition to other antimicrobial products. Adailydoseis 600 mgperday. In case of the severe forms of the infectious processes, a dose for adults may be increased by two times, and so Rifampicin 600 mg is used 2 times per day, with the interval of 8-10 hours.
What are side effects?
Skin, begma, sweat, stool, tear fluid, and urine may be orange-red due to the treatment with Rifampicin. This is a temporal discomfort which happens only after the end of the treatment.
Moreover, the following side effects may happen during the treatment: nausea, vomiting, diarrhea, shivers, and headache. These side effects may speak for a high dose. A reduction of the daily dose helps to lower the intensity of the side effects.
- To prevent a development of the resistance of microorganisms, it is necessary to use the drug with other antimicrobial products
- The use of Rifampicin is contraindicated during pregnancy
- Peripheral blood and liver functions should be controlled during a prolonged use of Rifampicin
- The use of Rifampicin is contraindicated during severe chronic diseases of liver.