According to statistics, about 2,5 million people have epilepsy in the USA. There are more than 40 forms of epilepsy, and an individual medical product should be selected that will work better in every medical case. One of the most universal drugs for the treatment of epilepsy is Topamax.
Topamax is an antiepileptic medicine which has been approved by FDA and is actively used in medical practice. It contains an active ingredient Topiramate which is not a tranquilizer and has a specific action to the central nervous system.
According to the structure, Topamax is a derivative of fructose. Its action happens by means of the regulation of the neuron activity in the central nervous system and interaction with GABA receptors.
The use of Topamax helps to reduce the frequency of the appearance of the convulsive attacks and also to relieve their course. Many doctors state that Topamax is not the strongest product for epilepsy but it has a broader action and may be used as a second-line product during epilepsy and affections of the central nervous system.
Topamax helps to arrest headache during migraine, may be used to reduce an excessive weight and is effective during some forms of the bipolar disorder.
Indications for the use
- Epilepsy (partial or generalized seizures)
- Migraine Prevention
- Treatment of alcohol/drug intoxication
- Treatment of mania due to bipolar disorder
In what dose is Topamax used?
Tablets/capsules of Topamax are taken orally at the same time every day. In order to maintain a stable therapeutic effect, it is necessary to take a medicine on a regular basis without missing any dose.
To select a working daily dose, the treatment begins from the minimal dose of Topamax 50 mg per day. The daily dose is increased by 25-50 mg every 7 days depending on the intensity of the therapeutic action.
The optimal daily dose of Topamax is 400 mg (a tablet/capsule of Topamax 200 mg in the morning and evening) for an adult patient.
The daily dose can be 1600 mg during severe forms of epilepsy and frequent attacks.
In case of the overdose with Topamax, the frequency and intensity of the side effects such as psychomotor retardation, abnormal thinking, cognitive disorders, vomiting, allergic reactions, and liver failure are increased.
In case of the overdose, a symptomatic therapy and a gastric lavage are done. A patient is controlled within 7 days until the functions of the central nervous system are not restored.
- Topamax does not influence on the pharmacological characteristics of Phenobarbital, valproic acid, phenytoin and carbamazepine, and therefore these medicines may be used in the combined therapy of epilepsy.
- Using Topamax, it is necessary to refuse from drugs which provide an inhibiting or stimulating action to the central nervous system
- The use of the drug should be gradually stopped in order to cut down on the frequency of the attacks. The dose should be reduced by 100 mg every week
- Topamax is not prescribed patients under 2 years old, pregnant women and patients with allergy to Topiramate
- Patients taking Topamax should avoid alcohol consumption.